How long do I need to wait between IVF cycles? Is it better to take a break between IVF cycles? What is the time I should wait between fertility treatments? These are all questions that fertility specialists get asked quite frequently. Dr. Marcy Maguire, a reproductive endocrinologist at RMA, answers all of your questions.


I had an unsuccessful IVF or IUI treatment cycle. Should I wait some time before trying to conceive again or should I try sooner rather than later?

Our approach is to carefully evaluate every unsuccessful cycle and optimize the next one. What kind of treatment cycle have you just completed?


How Long Should You Wait Between IUI Cycles?

In general, for women who ovulate regularly and have unexplained infertility, I recommend up to three months of Clomid in conjunction with intrauterine insemination (IUI). Clomid is an oral medication regularly prescribed for ovulation induction or for patients with unexplained infertility.

In women who do not ovulate regularly due to polycystic ovarian disease (PCOS), I would consider three or four cycles of Femara with intrauterine insemination.

Femara is an oral medication approved by the United States Food and Drug Administration (FDA) for the treatment of breast cancer. The medication has been used by reproductive endocrinologists since 2000 for its off-label use of ovulation induction.

Letrozole has been shown to be more effective than Clomid for women with PCOS.


How Long Should You Wait Between IVFCycles?

Fresh in vitro fertilization cycles should not be performed in back-to-back months. It is our practice’s approach to take one month off after a fresh cycle of IVF prior to embarking on another fresh cycle of IVF.

Alternatively, we are very comfortable – and have had high pregnancy rates, doing a frozen embryo transfer immediately following a fresh IVF cycle.

Individualizing treatment protocols for each patient maximizes pregnancy rates.

Our practice is exceptionally hands-on. Each patient works closely with a single physician to choose the next treatment cycle to help couples conceive in the shortest amount of time possible.


Infertility Treatment FAQs with Dr. Marcy Maguire


Dr. Marcy Maguire of RMANJ discusses top infertility FAQ's on Facebook Live!